Global Distribution of Tropical Diseases

Communities of practice Partnerships

South-South Initiative for Tropical Diseases Research
Initiative to Strengthen Health Research Capacity in Africa (ISHReCA)
Malaria Eradication Research Agenda (malERA)
Research Partnerships for Neglected Diseases of Poverty

Content Type: Research Articles

Disease: African Trypanosomiasis

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Registered users may save selected Research Articles, Review Articles and Editorials to the My Articles area of My Virtual Journals.

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20 May 2010

New drugs still lacking for the infectious diseases of poverty

So far in the 21st century (and with the exception of malaria and AIDS), only four new products have become available for treating or preventing infections in poor communities.
Source: PLoS ONE
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16 Apr 2010

Sleeping sickness: could a new drug be in prospect?

Researchers have identified a molecular target for drugs to treat human African trypanosomiasis (sleeping sickness). Clinical trials of a new drug could begin as early as next year.
Source: Nature
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14 Apr 2010

Leishmaniasis attracts increased attention from researchers looks at some recent research publications on a much-neglected infectious disease of poverty.

1 Mar 2010

In brief

Some recently published studies on the infectious diseases of poverty.
Source: Journal articles

7 Jul 2009

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

Study shows that a combination therapy for sleeping sickness is safer and easier to administer.
Source: Lancet
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4 Sep 2008

The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice

To neutralize circulating antibodies, T. brucei brucei performs waves of antigenic switch.
Source: PLoS Pathogens
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25 Jul 2008

Analysis of risk factors for T. brucei rhodesiense sleeping sickness within villages in south-east Uganda

Improved understanding of who is most at risk will aid in the development of control programmes.
Source: BMC Infectious Diseases
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18 Jun 2008

Neglected Diseases in the News: A Content Analysis of Recent International Media Coverage Focussing on Leishmaniasis and Trypanosomiasis

Study shows that neglected tropical diseases attract little attention from the media.
Source: PLoS Neglected Tropical Diseases
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5 Mar 2008

Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: cohort study

Eflornithine is the only alternative to melarsoprol currently registered for the treatment of second-stage human African trypanosomiasis. A study in the Sudan shows it to have acceptable safety and effectiveness as a first-line treatment.
Source: BMJ
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