Research Articles Results  

14 Aug 2008

Co-infections: a neglected research priority

Infection with multiple parasites is increasingly being observed in the tropics however there is very little research activity on its impact on public health.
Source: Parasitology
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6 Aug 2008

Safety and Immunogenicity of a Malaria Vaccine, Plasmodium falciparum AMA-1/MSP-1 Chimeric Protein Formulated in Montanide ISA 720 in Healthy Adults

A study finds the candidate vaccine PfCQ29 to be safe and immunogenic.
Source: PLoS ONE
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6 Aug 2008

A Randomized Placebo-Controlled Trial of Intermittent Preventive Treatment in Pregnant Women in the Context of Insecticide Treated Nets Delivered through the Antenatal Clinic

IPTp reduced parasitaemia prevalence but had no impact on maternal or birth outcomes. Implementation of IPTp may not be required if ITNs are used.
Source: PLoS ONE
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4 Aug 2008

Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes

Authors apply a large-scale gene knockout strategy combined with functional screening to identify the proteins that active malaria’s exporteome.
Source: Cell
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4 Aug 2008

Does resistance to filarial reinfections become leaky over time?

Authors develop theoretical models to explain the dynamics of population control of long-lived parasites in their hosts systems.
Source: Trends in Parasitology
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1 Aug 2008

Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial

IPT of malaria improves the health and cognitive ability of schoolchildren in an area of high perennial transmission.The reduction of the malaria burden requires not only effective treatment but development programmes for the poorest that include action on environmental sanitation, water supply and nutrition. Efforts intended to improve performance at school should not focus exclusively on health factors. Poverty itself is strongly associated with poor levels of attention in schoolchildren.
Source: The Lancet
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25 Jul 2008

Chemoprophylaxis and intermittent treatment for preventing malaria in children

Encouraging results from 21 trials but more research is still needed.
Source: Cochrane Database of Systematic Reviews
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25 Jul 2008

Antimalarial drug use in general populations of tropical Africa

There appear to be very wide variations in levels of antimalarial use between and within different locations.
Source: Malaria Journal
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25 Jul 2008

Analysis of risk factors for T. brucei rhodesiense sleeping sickness within villages in south-east Uganda

Improved understanding of who is most at risk will aid in the development of control programmes.
Source: BMC Infectious Diseases
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21 Jul 2008

The value of molecular studies for the diagnosis of Congenital Chagas Disease in North eastern Argentina

PCR testing has been found to detect more cases in neonates, highlighting the need to improve the sensitivity of diagnosis.
Source: American Journal of Tropical Medicine and Hygiene
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