Research Articles Results  

21 Aug 2007

Increasing Coverage and Decreasing Inequity in Insecticide-Treated Bed Net Use among Rural Kenyan Children

Noor and colleagues found low levels of use of insecticide-treated mosquito nets when nets were mainly available through the commercial sector. Levels increased when subsidized nets were introduced and rose further when they were made available free.
Source: PLoS Medicine
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21 Aug 2007

Defining Childhood Severe Falciparum Malaria for Intervention Studies

The accepted definition of severe malaria is appropriate for clinical purposes, but Philip Bejon and colleagues show its specificity in clinical trials may be improved by a parasite density threshold and by excluding children with certain conditions.
Source: PLoS Medicine
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21 Aug 2007

Improving Case Definitions for Severe Malaria

The authors discuss a study by Philip Bejon et al. that adopted a new approach to balancing the sensitivity and specificity of criteria for defining severe malaria.
Source: PLoS Medicine
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7 Aug 2007

Development of New Tuberculosis Vaccines: A Global Perspective on Regulatory Issues

What are the regulatory challenges for testing and introducing investigative TB vaccines into countries where the disease is endemic?
Source: PLoS Medicine
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3 Jul 2007

Preventing Childhood Malaria in Africa by Protecting Adults from Mosquitoes with Insecticide-Treated Nets

Based on malaria transmission models, Gerry Killeen and colleagues suggest that, while coverage of pregnant women and children should still be prioritized, wide-scale communal use of insecticide-treated bed nets would provide considerable benefit to vulnerable groups and should be promoted and evaluated in the field.
Source: PLoS Medicine
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12 Jun 2007

Commercial Serological Antibody Detection Tests for the Diagnosis of Pulmonary Tuberculosis: A Systematic Review

Based on a systematic review, Madhukar Pai and colleagues conclude that none of the commercial immune-based tests for pulmonary tuberculosis so far evaluated perform well enough to replace sputum smear microscopy.
Source: PLoS Medicine
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12 Jun 2007

Serial Testing for Tuberculosis: Can We Make Sense of T Cell Assay Conversions and Reversions?

The authors discuss a new study, which they say is a valuable addition to the existing literature on the performance of interferon gamma release assays in serial testing for TB infection.
Source: PLoS Medicine
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29 May 2007

HIV Impairs Opsonic Phagocytic Clearance of Pregnancy-Associated Malaria Parasites

Based on a comparison of HIV-negative or HIV-infected primigravid and multigravid women, Kevin Kain and colleagues suggest that opsonic phagocytosis might protect against pregnancy-associated malaria, and that HIV infection might impair this parasite clearance mechanism.
Source: PLoS Medicine
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1 May 2007

Malnutrition and Infection: Complex Mechanisms and Global Impacts

The authors discuss current concepts and controversies surrounding the complex influences of malnutrition on infection and immunity, and point to practical consequences of countermeasures in acute malnutrition.
Source: PLoS Medicine
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10 Apr 2007

Malaria in Pregnancy: What Can the Social Sciences Contribute?

Building on existing knowledge from social science work on malaria, the authors propose two models for studying social science aspects of malaria in pregnancy.
Source: PLoS Medicine
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