Research Articles Results  

9 Apr 2008

A Randomized Placebo-Controlled Trial of Intermittent Preventive Treatment in Pregnant Women in the Context of Insecticide Treated Nets Delivered through the Antenatal Clinic

Few clinical trials have studied the effects of antimalarial interventions used in combination. A study from Mozambique has examined the combined use of insecticide-treated bednets (ITNs) and intermittent preventive treatment (IPTp) during pregnancy. The authors conclude that use of ITNs during pregnancy may reduce the need to administer IPTp, and that ITNs should be part of antenatal care in sub-Saharan Africa.
Source: PLoS ONE
PubMed Record | Read... | PDF

9 Apr 2008

The Effect of Diagnostic Delays on the Drop-Out Rate and the Total Delay to Diagnosis of Tuberculosis

Delays in tuberculosis diagnosis are critical as infected individuals remain untreated in the community, providing more opportunities for transmission of the disease. An analysis of the factors responsible for such delays reinforces the urgent need for novel diagnostic methods, both for smear positive and negative TB, that are highly sensitive, accessible and point of care, in order to reduce delays.
Source: PLoS ONE
PubMed Record | Read... | PDF

1 Apr 2008

Cytological and Transcript Analyses Reveal Fat and Lazy Persister-Like Bacilli in Tuberculous Sputum

New light is shed on how M. tuberculosis protects itself and on how drug resistance develops.
Source: PLoS Medicine
PubMed Record | Read... | PDF

1 Apr 2008

Identification of oxadiazoles as new drug leads for the control of schistosomiasis

Encouraging results from in vitro and mice studies identify oxadiazole 2-oxides as new lead compounds for schistosomiasis chemotherapy
Source: Nature Medicine
PubMed Record | Read...

28 Mar 2008

Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies

Rectal administration of artemisinin derivatives has potential for early treatment for severe malaria in remote settings where injectable antimalarial therapy may not be feasible.
Source: BMC Infectious Diseases
PubMed Record | Read... | PDF

28 Mar 2008

The Influence of Host and Bacterial Genotype on the Development of Disseminated Disease with Mycobacterium tuberculosis

New findings suggest that the outcome of exposure to M. tuberculosis can depend on both the human genotype and the bacterial genotype.
Source: PLoS Pathogens
PubMed Record | Read... | PDF

27 Mar 2008

Congenital Chagas’ disease: diagnostic and clinical aspects in an area without vectorial transmission, Bermejo, Bolivia

A study shows that congenital transmission of Chagas’ disease can occur even in countries where the disease vector is absent.
Source: Acta Tropica
PubMed Record | Read...

26 Mar 2008

First Cultivation and Characterization of Mycobacterium ulcerans from the Environment

The isolation and characterisation of a strain of M. ulcerans supports the concept that the organism is a pathogen of humans with an aquatic environmental niche.
Source: PLoS Neglected Tropical Diseases
PubMed Record | Read... | PDF

26 Mar 2008

Rabies Diagnosis for Developing Countries

Canine rabies is a neglected disease causing 55,000 human deaths worldwide per year. The gold standard test for rabies diagnosis requires a fluorescent microscope, which is available in very few centres in developing countries. An evaluation of a new test, conducted in Chad has produced encouraging results.
Source: PLoS Neglected Tropical Diseases
PubMed Record | Read... | PDF

19 Mar 2008

Overestimates of Survival after HAART: Implications for Global Scale-Up Efforts

After tracing of patients lost to follow-up from Botswana’s National Antiretroviral Therapy Programme, it was found that over half of these patients had died. In low-resource environments, inadequate follow-up may lead to overestimates of survival.
Source: PLoS ONE
PubMed Record | Read... | PDF